Due to the location of the liver and its proximity to the nerves of the diaphragm, liver problems can radiate pain to the back, particularly the upper right side, and even to the right shoulder.
This radiating pain is known as referred pain, as the brain can interpret discomfort from the liver as if it were coming from other parts of the body. People with chronic liver disease or liver tumors often experience this discomfort in the back or shoulders.

3. General abdomen (widespread abdominal pain)
In some people, liver problems may manifest as pain that spreads throughout the abdomen, rather than being localized exclusively to the right side. This can occur if liver inflammation affects other nearby organs or if fluid builds up in the abdomen, known as ascites.
Ascites can cause a feeling of bloating, heaviness, and general discomfort in the abdominal area, typical of cases of advanced cirrhosis or liver failure.
4. Skin and joints
Liver problems can affect not only internal organs but also the skin and joints. A liver condition called cholestasis, in which bile flow is obstructed, can cause intense itching all over the body, especially on the palms and soles.
Additionally, the accumulation of toxins in the body due to poor liver function can cause inflammation and joint pain, known as hepatic arthritis.
5. Headache and general tiredness

While not directly associated with pain in a specific organ, liver problems can also cause headaches and extreme fatigue. The liver plays a crucial role in eliminating toxins from the body, and when it malfunctions, these toxins can build up, affecting the brain and causing confusion, frequent headaches, and debilitating fatigue.
This condition, known as hepatic encephalopathy, can cause widespread headaches and a general feeling of malaise.
It can manifest itself in multiple areas or in just one.
Pain related to liver problems can manifest itself in various parts of the body, from the abdomen to the back, shoulders, and joints.
If you experience persistent pain in these areas along with other symptoms such as jaundice (yellowing of the skin and eyes), abdominal swelling, fatigue, and confusion, it’s important to consult a doctor for a complete evaluation of your liver function. Early treatment of liver disease can help prevent serious complications and improve your quality of life.
